Adreno-Mend

The response to chronic stress - first defined as occurring in three stages by Hans Selye as alarm, resistance and exhaustion - typically results in aberrant adrenal function and adrenal fatigue, as well as abnormal cognitive, metabolic, energy, endurance, immune and glycemic function. The consequences of intermittent stress, or episodic acute stress during resistance or exhaustion, interfere with recovery and also promote abnormal neuroendocrine, metabolic and immune system function. The plant adaptogens in Adreno-Mend™ effectively address all stages of both acute and chronic stress, support the body’s ability to adapt to stressors and help avoid the damaging consequences from those stressors. Collectively, plant adaptogens can support symptoms of fatigue and enhance endurance as well as support normal mental and emotional well being. Plant adaptogens also can increase the body’s ability to resist and recover from stress while providing an overall feeling of balance and normalization. † During acute stress, and the alarm stage of stress, Rhodiola rosea, Schizandra chinensis, Bacopa monnieri, and Eleutherococcus senticosus can support mental performance and physical working capacity, as well as promote the balanced response of the sympatho-adrenalsystem (SAS) to the body’s acute reaction to a stressor. During the resistance stage Withania somnifera, Coleus forskohlii, are able to support the normal thyroid and gonadal. function. In the exhaustion stage the Rehmannia glutinosa, Bupleurum falcatum and Withania somnifera act as primary agents to restore proper function of the hypothalamic-pituitary-adrenal axis and work synergistically with other plant adaptogens to support normal function of other body systems. Adaptogens with adrenotrophic properties may also decrease adrenal atrophy seen in the exhaustion stage of chronic stress. The increased cortisol levels seen in various stages of stress are modulated by Schizandra chinensis and Magnolia officinalis. Rehmannia glutinosa can help restore normal function of glucocorticoid receptors that have been down regulated due to chronically elevated levels of cortisol. Bupleurum falcatum supports adrenal recovery and normalization of the hypothalamicpituitary- adrenal (HPA) system by promoting the release of adrenocorticotropic hormone (ACTH), which is responsible for maintaining the normal size and function of the adrenal gland. Stress induced elevations of catecholamines and adrenaline-induced hyperglycemia can be modulated by Magnolia officinalis, Panax ginseng and Rehmannia glutinosa. † While the primary benefit of plant adaptogens is the ability to restore healthy, balanced adrenal gland function by supporting normal hypothalamic-pituitary-adrenal (HPA) axis function, the effectiveness of these adaptogens is in large part also due to their ability to protect and promote the recovery of neuro-cognitive, neuromuscular, cardiovascular, glycemic, hepatic, thyroid, gonadal and immune system health.